AT OHSU

Molecular Probes for Surgical Guidance and Early Disease Detection

The Wang Lab at Oregon Health & Science University develops innovative fluorescent small-molecule imaging probes and bioconjugation strategies to translate chemical tools from bench to bedside. Our research focuses on near-infrared (NIR) and shortwave-infrared (SWIR) probes for fluorescence-guided surgery and noninvasive early disease detection. Current projects include targeted fluorescent agents for head-and-neck cancer surgery; technologies to enhance precision in pancreatic cancer resection and detection; imaging tools for quantitative, multiplexed spatial-proteomic characterization of complex tissues; and retinal fluorescence probes for noninvasive early detection of Alzheimer’s disease. Together these efforts aim to improve intraoperative decision-making, enable earlier diagnosis, and accelerate clinical translation of quantitative molecular imaging.